Cathodoluminescence and electron microscopy of red quantum dots used for display applications

Cathodoluminescent imaging of the visible light emitted from quantum dots is reported. The shape and uniformity of individual particles is observed in the STEM electron image and the image of the particles created from their visible light collected simultaneously is shown. Visible light images of the 13nm sized particles are reported for clusters of particles. Emission spectra collected from a small clusters of QDs are also reported

Exact active subspace Metropolis-Hastings, with applications to the Lorenz-96 system

We consider the application of active subspaces to inform a Metropolis-Hastings algorithm, thereby aggressively reducing the computational dimension of the sampling problem. We show that the original formulation, as proposed by Constantine, Kent, and Bui-Thanh (SIAM J. Sci. Comput., 38(5):A2779-A2805, 2016), possesses asymptotic bias. Using pseudo-marginal arguments, we develop an asymptotically unbiased variant. Our algorithm is applied to a synthetic multimodal target distribution as well as a Bayesian formulation of a parameter inference problem for a Lorenz-96 system

Deceleration of the solar wind in the Earth foreshock region: ISEE 2 and IMP 8 observations

The deceleration of the solar wind in the region of the interplanetary space filled by ions backstreaming from the Earth bow shock was studied using a two spacecraft technique. This deceleration, which is correlated with the "diffuse" but not with the "reflected" ion population, depends on the solar wind bulk velocity: at low velocities (below 300 km/sec) the velocity decrease is about 5 km/sec, while at higher velocities (above 400 km/sec) the decrease may be as large as 30 km/sec. Along with this deceleration, the solar wind undergoes a deflection of about 1 deg away from the direction of the Earth bow shock. The energy balance shows that the kinetic energy loss far exceeds the thermal energy which is possibly gained by the solar wind, therefore, at least part of this energy must go into waves and/or into the backstreaming ions

Long-term earnings losses of high-seniority displaced workers

Displaced workers

The gray matter structural connectome and its relationship to alcohol relapse: Reconnecting for recovery.

Gray matter (GM) atrophy associated with alcohol use disorders (AUD) affects predominantly the frontal lobes. Less is known how frontal lobe GM loss affects GM loss in other regions and how it influences drinking behavior or relapse after treatment. The profile similarity index (PSI) combined with graph analysis allows to assess how GM loss in one region affects GM loss in regions connected to it, ie, GM connectivity. The PSI was used to describe the pattern of GM connectivity in 21 light drinkers (LDs) and in 54 individuals with AUD (ALC) early in abstinence. Effects of abstinence and relapse were determined in a subgroup of 36 participants after 3 months. Compared with LD, GM losses within the extended brain reward system (eBRS) at 1-month abstinence were similar between abstainers (ABST) and relapsers (REL), but REL had also GM losses outside the eBRS. Lower GM connectivities in ventro-striatal/hypothalamic and dorsolateral prefrontal regions and thalami were present in both ABST and REL. Between-networks connectivity loss of the eBRS in ABST was confined to prefrontal regions. About 3 months later, the GM volume and connectivity losses had resolved in ABST, and insula connectivity was increased compared with LD. GM losses and GM connectivity losses in REL were unchanged. Overall, prolonged abstinence was associated with a normalization of within-eBRS connectivity and a reconnection of eBRS structures with other networks. The re-formation of structural connectivities within and across networks appears critical for cognitive-behavioral functioning related to the capacity to maintain abstinence after outpatient treatment

Is there Evidence for a Hubble bubble? The Nature of Type Ia Supernova Colors and Dust in External Galaxies

We examine recent evidence from the luminosity-redshift relation of Type Ia Supernovae (SNe Ia) for the $\sim 3 \sigma$ detection of a ``Hubble bubble'' -- a departure of the local value of the Hubble constant from its globally averaged value \citep{Jha:07}. By comparing the MLCS2k2 fits used in that study to the results from other light-curve fitters applied to the same data, we demonstrate that this is related to the interpretation of SN color excesses (after correction for a light-curve shape-color relation) and the presence of a color gradient across the local sample. If the slope of the linear relation ($\beta$) between SN color excess and luminosity is fit empirically, then the bubble disappears. If, on the other hand, the color excess arises purely from Milky Way-like dust, then SN data clearly favors a Hubble bubble. We demonstrate that SN data give $\beta \simeq 2$, instead of the $\beta \simeq 4$ one would expect from purely Milky-Way-like dust. This suggests that either SN intrinsic colors are more complicated than can be described with a single light-curve shape parameter, or that dust around SN is unusual. Disentangling these possibilities is both a challenge and an opportunity for large-survey SN Ia cosmology.Comment: Further information and data at http://qold.astro.utoronto.ca/conley/bubble/ Accepted for publication in ApJ

Doxycycline alters metabolism and proliferation of human cell lines.

The tetracycline antibiotics are widely used in biomedical research as mediators of inducible gene expression systems. Despite many known effects of tetracyclines on mammalian cells-including inhibition of the mitochondrial ribosome-there have been few reports on potential off-target effects at concentrations commonly used in inducible systems. Here, we report that in human cell lines, commonly used concentrations of doxycycline change gene expression patterns and concomitantly shift metabolism towards a more glycolytic phenotype, evidenced by increased lactate secretion and reduced oxygen consumption. We also show that these concentrations are sufficient to slow proliferation. These findings suggest that researchers using doxycycline in inducible expression systems should design appropriate controls to account for potential confounding effects of the drug on cellular metabolism

The On The Fly Imaging Technique

The On-The-Fly (OTF) imaging technique enables single-dish radio telescopes to construct images of small areas of the sky with greater efficiency and accuracy. This paper describes the practical application of the OTF imaging technique. By way of example the implementation of the OTF imaging technique at the NRAO 12 Meter Telescope is described. Specific requirements for data sampling, image formation, and Doppler correction are discussed.Comment: 10 pages, 13 figures, accepted A&